徐梅;吴昌平;蒋敬庭;

• 1:江苏省徐州市中心医院妇产科
• 2:江苏省苏州大学附属第三医院肿瘤生物诊疗中心

摘要(Abstract)：

microRNAs(miRNAs或miRs)是一类在转录后水平调控基因表达的单链非编码小分子RNA。miRNA能调控机体多种生理和病理过程,如细胞增殖、分化、发育、凋亡、激素分泌和肿瘤形成等。miRNA在卵巢癌中表达异常,与卵巢癌的发生、发展、转移和耐药密切相关,提示其有望成为卵巢癌的诊断标记物,并为预后评估、化疗耐药分析和个性化治疗提供临床思路。

关键词(KeyWords)： 卵巢肿瘤;miRNA;进展

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(No:81171653、30972703);; 江苏省自然科学基金项目(No:BK2011246、BK2011247);; 常州市科技基础设施滚动计划项目(No:2010148);; 常州市国际科技合作项目(No:CZ20110024)

作者(Authors): 徐梅;吴昌平;蒋敬庭;

DOI: 10.13283/j.cnki.xdfckjz.2013.07.023

参考文献(References)：

• [1]Siegel R,Naishadham D,Jemal A.Cancer statistics,2012[J].CA Cancer J Clin,2012,62(1):10-29
• [2]Tay Y,Zhang J,Thomson AM,et al.MicroRNAs toNanog,Oct4 and Sox2 coding regions modulate embryon-ic stem cell differentiation[J].Nature,2008,455(7216):1124-1128
• [3]Lopez-Camarillo C,Marchat LA,Arechaga-Ocampo E,etal.MetastamiRs:Non-Coding MicroRNAs Driving CancerInvasion and Metastasis[J].Int J Mol Sci,2012,13(2):1347-1379
• [4]Lu J,Getz G,Miska EA,et al.MicroRNA expression pro-files classify human cancers[J].Nature,2005,435(7043):834-838
• [5]Iorio MV,Visone R,Di Leva G,et al.MicroRNA signa-tures in human ovarian cancer[J].Cancer Res,2007,67(18):8699-8707
• [6]Dahiya N,Sherman-Baust CA,Wang TL,et al.MicroRNAexpression and identification of putative miRNA targets inovarian cancer[J].PLoS One,2008,3(6):e2436
• [7]Yang H,Kong W,He L,et al.MicroRNA expression profi-ling in human ovarian cancer:miR-214 induces cell sur-vival and cisplatin resistance by targeting PTEN[J].Cancer Res,2008,68(2):425-433
• [8]Nam EJ,Yoon H,Kim SW,et al.MicroRNA expressionprofiles in serous ovarian carcinoma[J].Clin CancerRes,2008,14(9):2690-2695
• [9]Lou Y,Yang X,Wang F,et al.MicroRNA-21 promotes thecell proliferation,invasion and migration abilities in ovari-an epithelial carcinomas through inhibiting the expressionof PTEN protein[J].Int J Mol Med,2010,26(6):819-827
• [10]Wyman SK,Parkin RK,Mitchell PS,et al.Repertoire ofmicroRNAs in epithelial ovarian cancer as determined bynext generation sequencing of small RNA cDNA libraries[J].PLoS One,2009,4(4):e5311
• [11]Zhang L,Volinia S,Bonome T,et al.Genomic and epige-netic alterations deregulate microRNA expression in hu-man epithelial ovarian cancer[J].Proc Natl Acad SciUSA,2008,105(19):7004-7009
• [12]Corney DC,Flesken-Nikitin A,Godwin AK,et al.Mi-croRNA-34b and MicroRNA-34c are targets of p53 andcooperate in control of cell proliferation and adhesion-in-dependent growth[J].Cancer Res,2007,67(18):8433-8438
• [13]Corney DC,Hwang CI,Matoso A,et al.Frequent down-regulation of miR-34 family in human ovarian cancers[J].Clin Cancer Res,2010,16(4):1119-1128
• [14]Giannakakis A,Sandaltzopoulos R,Greshock J,et al.miR-210 links hypoxia with cell cycle regulation and isdeleted in human epithelial ovarian cancer[J].CancerBiol Ther,2008,7(2):255-264
• [15]Zhang H,Zuo Z,Lu X,et al.MiR-25 regulates apoptosisby targeting Bim in human ovarian cancer[J].OncolRep,2012,27(2):594-598
• [16]Cheng W,Liu T,Wan X,et al.MicroRNA-199a targetsCD44 to suppress the tumorigenicity and multidrug re-sistance of ovarian cancer-initiating cells[J].FEBS J,2012,279(11):2047-2059
• [17]Chen J,Wang L,Matyunina LV,et al.Overexpression ofmiR-429 induces mesenchymal-to-epithelial transition(MET)in metastatic ovarian cancer cells[J].GynecolOncol,2011,121(1):200-205
• [18]Park SM,Gaur AB,Lengyel E,et al.The miR-200 familydetermines the epithelial phenotype of cancer cells bytargeting the E-cadherin repressors ZEB1 and ZEB2[J].Genes Dev,2008,22(7):894-907
• [19]Bendoraite A,Knouf EC,Garg KS,et al.Regulation ofmiR-200 family microRNAs and ZEB transcription fac-tors in ovarian cancer:evidence supporting a mesothelial-to-epithelial transition[J].Gynecol Oncol,2010,116(1):117-125
• [20]Cochrane DR,Spoelstra NS,Howe EN,et al.MicroRNA-200c mitigates invasiveness and restores sensitivity to mi-crotubule-targeting chemotherapeutic agents[J].MolCancer Ther,2009,8(5):1055-1066
• [21]Cowden Dahl KD,Dahl R,Kruichak JN,et al.The epi-dermal growth factor receptor responsive miR-125a re-presses mesenchymal morphology in ovarian cancer cells[J].Neoplasia,2009,11(11):1208-1215
• [22]Li J,Liang S,Yu H,et al.An inhibitory effect of miR-22on cell migration and invasion in ovarian cancer[J].Gy-necol Oncol,2010,119(3):543-548
• [23]李俊,梁山辉,鹿欣.与ezrin基因表达相关的微小RNA的筛选及在卵巢上皮性癌浸润转移中的作用[J].中华妇产科杂志,2010,45(10):787-792
• [24]Fan X,Liu Y,Jiang J,et al.miR-20a promotes prolifera-tion and invasion by targeting APP in human ovariancancer cells[J].Acta Biochim Biophys Sin(Shanghai),2010,42(5):318-324
• [25]梁山辉,李俊,Al-beit M,等.卵巢上皮恶性肿瘤侵袭转移相关miRNA的筛选与鉴定[J].中华肿瘤杂志,2010,32(9):650-654
• [26]Park SM,Shell S,Radjabi AR,et al.Let-7 prevents earlycancer progression by suppressing expression of the em-bryonic gene HMGA2[J].Cell Cycle,2007,6(21):2585-2590
• [27]Wu H,Cao Y,Weng D,et al.Effect of tumor suppressorgene PTEN on the resistance to cisplatin in human ovari-an cancer cell lines and related mechanisms[J].CancerLett,2008,271(2):260-271
• [28]Yang L,Li N,Wang H,et al.Altered microRNA expres-sion in cisplatin-resistant ovarian cancer cells and upreg-ulation of miR-130a associated with MDR1/P-glycopro-tein-mediated drug resistance[J].Oncol Rep,2012,28(2):592-600
• [29]Sorrentino A,Liu CG,Addario A,et al.Role of microR-NAs in drug-resistant ovarian cancer cells[J].GynecolOncol,2008,111(3):478-486
• [30]Fu X,Tian J,Zhang L,et al.Involvement of microRNA-93,a new regulator of PTEN/Akt signaling pathway,inregulation of chemotherapeutic drug cisplatin chemosen-sitivity in ovarian cancer cells[J].FEBS Lett,2012,586(9):1279-1286
• [31]Ye G,Fu G,Cui S,et al.MicroRNA 376c enhances ovar-ian cancer cell survival by targeting activin receptor-likekinase 7:implications for chemoresistance[J].J CellSci,2011,124(Pt 3):359-368
• [32]Yang N,Kaur S,Volinia S,et al.MicroRNA microarray i-dentifies Let-7i as a novel biomarker and therapeutic tar-get in human epithelial ovarian cancer[J].Cancer Res,2008,68(24):10307-10314
• [33]Zhu H,Wu H,Liu X,et al.Role of MicroRNA miR-27aand miR-451 in the regulation of MDR1/P-glycoproteinexpression in human cancer cells[J].Biochem Pharma-col,2008,76(5):582-588
• [34]Li Z,Hu S,Wang J,et al.MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human o-varian cancer cells[J].Gynecol Oncol,2010,119(1):125-130
• [35]van Jaarsveld MT,Helleman J,Berns EM,et al.MicroR-NAs in ovarian cancer biology and therapy resistance[J].Int J Biochem Cell Biol,2010,42(8):1282-1290
• [36]Lu L,Katsaros D,de la Longrais IA,et al.Hypermethyla-tion of let-7a-3 in epithelial ovarian cancer is associatedwith low insulin-like growth factor-II expression and fa-vorable prognosis[J].Cancer Res,2007,67(21):10117-10122
• [37]Hu X,Macdonald DM,Huettner PC,et al.A miR-200microRNA cluster as prognostic marker in advanced o-varian cancer[J].Gynecol Oncol,2009,114(3):457-464
• [38]Chao A,Lin CY,Lee YS,et al.Regulation of ovariancancer progression by microRNA-187 through targetingDisabled homolog-2[J].Oncogene,2012,31(6):764-775
• [39]Flavin R,Smyth P,Barrett C,et al.miR-29b expressionis associated with disease-free survival in patients with o-varian serous carcinoma[J].Int J Gynecol Cancer,2009,19(4):641-647
• [40]Eitan R,Kushnir M,Lithwick-Yanai G,et al.Tumor mi-croRNA expression patterns associated with resistance toplatinum based chemotherapy and survival in ovariancancer patients[J].Gynecol Oncol,2009,114(2):253-259
• [41]Peng DX,Luo M,Qiu LW,et al.Prognostic implicationsof microRNA-100 and its functional roles in human epi-thelial ovarian cancer[J].Oncol Rep,2012,27(4):1238-1244
• [42]Lodes MJ,Caraballo M,Suciu D,et al.Detection of canc-er with serum miRNAs on an oligonucleotide microarray[J].PLoS One,2009,4(7):e6229
• [43]Taylor DD,Gercel-Taylor C.MicroRNA signatures oftumor-derived exosomes as diagnostic biomarkers of o-varian cancer[J].Gynecol Oncol,2008,110(1):13-21
• [44]Resnick KE,Alder H,Hagan JP,et al.The detection ofdifferentially expressed microRNAs from the serum of o-varian cancer patients using a novel real-time PCR plat-form[J].Gynecol Oncol,2009,112(1):55-59