子宫平滑肌肉瘤的化疗进展
王莎;王志启;王建六;
摘要(Abstract):
子宫平滑肌肉瘤是一种少见的恶性肿瘤,其复发及转移率高,预后差。化疗是子宫平滑肉瘤辅助治疗的首选,但尚无统一规范的方案。本文就近年子宫平滑肌肉瘤的各种化疗方案进行了归纳总结。
关键词(KeyWords): 子宫平滑肌肉瘤;化疗;临床缓解率;无进展生存;总体生存
基金项目(Foundation):
作者(Authors): 王莎;王志启;王建六;
DOI: 10.13283/j.cnki.xdfckjz.2014.09.024
参考文献(References):
- [1]D'Angelo E,Prat J.Uterine sarcomas:a review[J].Gynecol Oncol,2010,116(1):131-139
- [2]曹泽毅.中华妇产科学(临床版)[M].北京:人民卫生出版社,2011:637
- [3]Akers SN,Groman A,Odunsi K,et al.Adjuvant treatment for uterine leiomyosarcoma[J].Eur J Gynaecol Oncol,2013,34(5):409-414
- [4]Ricci S,Giuntoli RL,Eisenhauer E,et al.Does adjuvant chemotherapy improve survival for women with earlystage uterine leiomyosarcoma?[J].Gynecol Oncol,2013,131(3):629-633
- [5]Look KY,Sandler A,Blessing JA,et al.Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma:agynecologic oncology group(GOG)study[J].Gynecol Oncol,2004,92(2):644-647
- [6]Talbot SM,Keohan ML,Hesdorffer M,et al.A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma[J].Cancer,2003,98(9):1942-1946
- [7]Anderson S,Aghajanian C.Temozolomide in uterine leiomyosarcomas[J].Gynecol Oncol,2005,98(1):99-103
- [8]Sanfilippo R,Grosso F,Jones RL,et al.Trabectedin in advanced uterine leiomyosarcomas:a retrospective case series analysis from two reference centers[J].Gynecol Oncol,2011,123(3):553-556
- [9]Schoffski P,Ray-Coquard IL,Cioffi A,et al.Activity of eribulin mesylate in patients with soft-tissue sarcoma:a phase 2study in four independent histological subtypes[J].Lancet Oncol,2011,12(11):1045-1052
- [10]Omura GA,Major FJ,Blessing JA,et al.A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomas[J].Cancer,1983,52(4):626-632
- [11]Borden EC,Amato DA,Rosenbaum C,et al.Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas[J].J Clin Oncol,1987,5(6):840-850
- [12]Sutton GP,Blessing JA,Malfetano JH.Ifosfamide and doxorubicin in the treatment of advanced leiomyosarcomas of the uterus:agynecologic oncology group study[J].Gynecol Oncol,1996;62(2):226-229
- [13]Edmonson JH,Blessing JA,Cosin JA,et al.Phase II study of mitomycin,doxorubicin,and cisplatin in the treatment of advanced uterine leiomyosarcoma:a Gynecologic Oncology Group study[J].Gynecol Oncol,2002,85(3):507-510
- [14]Long HJ,Blessing JA,Sorosky J.Phase II trial of dacarbazine,mitomycin,doxorubicin,and cisplatin with sargramostim in uterine leiomyosarcoma:A Gynecologic Oncology Group study[J].Gynecol Oncol,2005,99(2):339-342
- [15]Harter P,Canzler U,Lueck H,et al.Pegylated liposomal doxorubicin and carboplatin in malignant mixed epithelial mesenchymal and mesenchymal gynecologic tumors:aphase II trial of the AGO study group[J].J Clin Oncol,2011,29(36):5093
- [16]Hensley ML,Blessing JA,Degeest K,et al.Fixed-dose rate gemcitabine plus docetaxel as second-line therapy for metastatic uterine leiomyosarcoma:a Gynecologic Oncology Group phase II study[J].Gynecol Oncol,2008,109(3):323-328
- [17]Hensley ML,Blessing JA,Mannel R,et al.Fixed-dose rate gemcitabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma:a Gynecologic Oncology Group phase II trial[J].Gynecol Oncol,2008,109(3):329-334
- [18]Duffaud F,Pautier P,Nguyen BB,et al.A pooled analysis of the final results of the two randomized phase II studies comparing gemcitabine vs.gemcitabine and docetaxel in patients with metastatic/relapsed leiomyosarcoma[C].Connective Tissue Oncology Society Annual Meeting Abstracts 2010,abstract 898573
- [19]Pautier P,Floquet A,Penel N,et al.Randomized multicenter and stratified phase II study of gemcitabine alone versus gemcitabine and docetaxel in patients with metastatic or relapsed leiomyosarcomas:a Federation Nationale des Centres de LutteContre le Cancer(FNCLCC)French Sarcoma Group Study(TAXOGEM study)[J].Oncologist,2012,17(9):1213-1220
- [20]Hensley ML,Wathen JK,Maki RG,et al.Adjuvant Therapy for High-Grade,Uterus-Limited Leiomyosarcoma[J].Cancer,2013,119(8):1555-1561
- [21]Garcia-Del-Muro X,Lopez-Pousa A,Maurel J,et al.Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with prviousely treated soft tissue sarcoma:a Spanish Group for Research on Sarcomas Study[J].J Clin Oncol,2011,29(18):2528-2533
- [22]O'Cearbhaill R,Zhou Q,Iasonos A,et al.Treatment of advanced uterine leiomyosarcoma with aromatase inhibitors[J].Gynecol Oncol,2010,116(3):424-429
- [23]Altman AD,Nelson GS,Chu P,et al.Uterine Sarcoma and Aromatase Inhibitors[J].Int J Gynecol Cancer,2012,22(6):1006-1012
- [24]Hensley ML,Sill MW,Scribner DR Jr,et al.Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma:A Gynecologic Oncology Group phase II study[J].Gynecol Oncol,2009,115(3):460-465
- [25]Sleijfer S,Ray-Coquard I,Papai Z,et al.Pazopanib,a multikinase angiogenesisinhibitor,in patients with relapsed or refractory advanced soft tissue sarcoma:a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group(EORTC study 62043)[J].J Clin Oncol,2009,27(19):3126-3132
- [26]Van der Graaf WT,Blay JY,Chawla SP,et al.Pazopanib for metastatic soft-tissue sarcoma(PALETTE):a randomised,double-blind,placebo-controlled phase 3trial[J].Lancet,2012,379(9829):1879-1886
- [27]Chawla SP,Blay J,Ray-Coquard IL et al.Results of the phase III,placebo-controlled trial(SUCCEED)evaluating the mTOR inhibitor ridaforolimus(R)as maintenance therapy in advanced sarcoma patients(pts)following clinical benefit from prior standard cytotoxic chemotherapy(CT)[J].J Clin Oncol,2011,29:606s[abstract 10005]
- [28]Brewer Savannah KJ,Demicco EG,Lusby K,et al.Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma[J].Clini Cancer Res,2012,18(17):4633-4645
- [29]Li B,Takeda T,Tsuiji K,et al.Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells[J].Int J Gynecol Cancer,2013,23(5):803-808
- [30]Verschraegen CF,Arias-Pulido H,Lee SJ,et al.Phase IB study of the combination of docetaxel,gemcitabine,and bevacizumab in patients with advanced or recurrent soft tissue sarcoma:the Axtell regimen[J].Ann Oncol,2012,23(3):785-790
- [31]Clinical Trials.gov Identifier:NCT01012297(18May2012,date last accessed)
- [32]Eskander RN,Randall LM,Sakai T,et al.Flavokawain B,a novel,naturally occurring chalcone,exhibits robust apoptotic effects and indues G2/M arrest of a uterine leiomyosarcoma cell line[J].J Obstet Gynaecol Res,2012,38(8):1086-1094
- [33]Pula G,Pistilli A,Montagnoli C,et al.The tricyclic antidepressant amitriptyline is cytotoxic to HTB114human leiomyosarcoma and induces p75NTR-dependent apoptosis[J].Anticancer Drugs,2013,24(9):899-910