控制性超促排卵对不孕妇女血脂代谢及血清瘦素的影响The influence of controlled ovarian hyperstimulation to serum lipid metabolism and leptin in infertilily women
张鹏;邹淑花;宋东坡;李波;
摘要(Abstract):
目的:探讨控制性超促排卵(COH)对不孕妇女血脂代谢及血清瘦素的影响。方法:接受体外授精-胚胎移植不孕妇女48例,以自身自然周期为对照,比较自然周期与促排卵周期在不同时间点血清高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、胆固醇(TG)、甘油三酯(TC)、瘦素(LEP)、雌二醇(E2)及孕酮(P)水平的变化,分析COH过程中血脂各因子及LEP的变化规律。结果:自然周期和促排卵周期血脂各指标无明显波动(P>0.05);HDL变化与雌激素水平呈正相关,LDL、TG、TC变化趋势与雌激素水平呈负相关;在自然周期LH出峰日LEP均值水平出现高峰,且明显高于相应自然周期月经第2天的LEP水平(P<0.05);COH周期HCG注射日LEP均值水平亦出现高峰,且明显高于促排卵周期月经第2天的LEP水平(P<0.05);血清LEP与血清E2呈正相关(P<0.05)。结论:短时间应用COH治疗对不孕女性脂代谢无不良影响。
关键词(KeyWords): 不育,女性;控制性超促排卵;血脂;受精,体外;胚胎移植;瘦素
基金项目(Foundation):
作者(Authors): 张鹏;邹淑花;宋东坡;李波;
DOI: 10.13283/j.cnki.xdfckjz.2010.03.012
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