游艳琴;宋磊;

• 1:解放军总医院妇产科
• 2:解放军总医院妇产科 北京100853
• 3:北京100853

摘要(Abstract)：

目的:探讨K i67、Bax与宫颈癌新辅助化疗疗效和预后之间的关系。方法:在新辅助化疗(neoad juvant chemotherapy,NACT)前后用免疫组化方法检测23例局部晚期宫颈癌组织K i67和Bax的表达。结果:临床总有效率为82.61%。化疗有反应者NACT前后K i67、Bax表达有统计学差异(P<0.05);无反应者NACT前后K i67、Bax表达无统计学差异(P>0.05)。不同病理类型和临床分期患者NACT前后K i67和Bax变化值无显著性差异;不同病理分级患者NACT前后Bax变化值有统计学差异(P<0.05)。NACT前K i67 LI>33%和K i67 LI<33%患者的平均无瘤生存期分别为48.6个月和19个月(P<0.05)。结论:K i67、Bax与化疗疗效显著相关。K i67、Bax有可能作为判断化疗疗效和预后的指标。

关键词(KeyWords)： 宫颈肿瘤;新辅助化疗;Ki-67抗原;Bax

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 游艳琴;宋磊;

DOI: 10.13283/j.cnki.xdfckjz.2006.11.005

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