Ki67和Bax在局部晚期宫颈癌新辅助化疗前后表达的意义The significance of Ki67 and Bax expressions before and after neoadjuvant chemotherapy in locally advanced cervical carcinoma.
游艳琴;宋磊;
摘要(Abstract):
目的:探讨K i67、Bax与宫颈癌新辅助化疗疗效和预后之间的关系。方法:在新辅助化疗(neoad juvant chemotherapy,NACT)前后用免疫组化方法检测23例局部晚期宫颈癌组织K i67和Bax的表达。结果:临床总有效率为82.61%。化疗有反应者NACT前后K i67、Bax表达有统计学差异(P<0.05);无反应者NACT前后K i67、Bax表达无统计学差异(P>0.05)。不同病理类型和临床分期患者NACT前后K i67和Bax变化值无显著性差异;不同病理分级患者NACT前后Bax变化值有统计学差异(P<0.05)。NACT前K i67 LI>33%和K i67 LI<33%患者的平均无瘤生存期分别为48.6个月和19个月(P<0.05)。结论:K i67、Bax与化疗疗效显著相关。K i67、Bax有可能作为判断化疗疗效和预后的指标。
关键词(KeyWords): 宫颈肿瘤;新辅助化疗;Ki-67抗原;Bax
基金项目(Foundation):
作者(Authors): 游艳琴;宋磊;
DOI: 10.13283/j.cnki.xdfckjz.2006.11.005
参考文献(References):
- [1]Rose PG.Locally advanced cervical cancer[J].CurrOp inGynecol,2001,13:65-70
- [2]Moore DH.Treatm ent of stageⅠB2(bu lky)cervical car-c inom a[J].Cancer Treat Rev,2003,29:401-406
- [3]F inanMA,Decesace S,F iorica JV,et al.Rad ical hysterec-tomy for stageⅠB1 vsⅠB2 carc inom a of the cervix:doesthe new staging system pred ict morb id ity and survival?[J].Gynecol Oncol,1996,62:139-147
- [4]Serur E,M athews RP,Gates J,et al.Neoad juvant chemo-therapy in stageⅠB2 squamous cell carc inom a of the cer-vix[J].Gynecol Oncol,1997,2:1049-1057
- [5]S in icrope FA,Ruan SB,C leary KR,et al.Bc l-2 and P53oncoprote in expression during colorectal tumorigenesis[J].Cancer Res,1995,55:237-241
- [6]M etz CE.Basic princ ip les ofROC analysis[J].Sem in Nu-c lM ed,1978,8:486-498
- [7]Sard i JE,G iaroli A,Sananes C,et al.Long-term follow-upof the first random ized trial using neoad juvant chemother-apy in stageⅠb squamous carc inom a of the cervix:the fi-nal resu lts[J].Gynecol Oncol,1997,67:61-69
- [8]M arth C,Sundfors K,Kaer J,et al.Long-term follow-up ofneoad juvant c isp latin and 5-fluorourac il chemotherapy inbu lky squamous cell carc inom a of the cervix[J].ActaOncol,1999,38:517-520
- [9]Zanetta G,Fe i F,M angion i C.Chemotherapy w ith pac lita-xel,ifosfam ide,and c isp latin for the treatm ent of squamouscell cervical cancer:the experience ofMonza[J].Sem inOncol,2002,27:23-27
- [10]Awhney N,Hallpa.K i67-structure,function and new an-tibod ies[J].J Pathol,1992,168:161-162
- [11]Kamoi S,Ohak i Y,Am ano Y,et al.Pre-treatm entm itoticindex versus computer-quantitated K i67 nuc lear antigenlabeling index as pred ictors of response to neoad juvantchemotherapy in uterine cervical carc inom a[J].N ipponM ed Sch,2003,70:219-226
- [12]Su ltana H,K igawa JY.Chemosensitivity and p53-Baxpathway-m ed iated apoptosis in patients w ith uterine cer-vical cancer[J].Annals of Oncology,2003:214-219
- [13]Okamoto E,Sum i T,M isugi F,et al.Expression of apop-tosis-related prote ins in advanced uterine cervical cancerafter ballon-occ luded arterial infusion chemotherapy asan ind icator of the effic iency of th is therapy[J].Int JMolM ed,2005,15:41-47
- [14]Fu jiwak i R,L ida K,Ohn ish i Y,et al.Intra-arterial neo-ad juvant chemotherapy followed by rad ical surgery andrad iotherapy for stageⅡb cervical carc inom a[J].Anti-cancer Res,1997,17:3751-3755