CDKI p27kip1与肿瘤
王刚
摘要(Abstract)：
CDKIp27kip1是近年发现的具有抑制细胞增殖、促进细胞凋亡、诱导细胞分化等多方面作用，极富研究及应用价值的抑癌因子。现就其与肿瘤的关系作一综述。
关键词(KeyWords)：
基金项目(Foundation):
作者(Author): 王刚
DOI: 10.13283/j.cnki.xdfckjz.1999.04.025
参考文献(References)：
- 1. Polyak K,Kato JY,Solomon MT,et al. p27kipl,a cylin-CdK inhibitor,links transforming growth factorbeta and contact inhibition to cell cycle arrest. Genes Dev, 1994; 8(1): 9
- 2. Pietenpol JA, Bohlander SK, Sato Y, et al. Assignment of the human P27 kipl gene to 12P13 and itsanalysis in leukemias. Cancer Res, 1995; 55 (6 ): 1206
- 3. Ponce-Castaneda MV, Lee MH Latres E, et al. P27 kipl chromosomal mapping to 12p12-12p13. 1 andabsence of mutations in human tumors. Cancer Res, 1995; 55 (6): 1211
- 4. Alessandrini A, Chiaur DS, Pagano M. Regulation of the cyclin-dependent kinase inhibitor P27 bydegradation and phosphorylation. Leukemia, 1997; 11: 342
- 5. Millard SS,Yan JS,Nguyen H, et al. Enhanced ribosomal association of P27 (kipl)mRNA is a mechanismcontributing to accumulation during growth arrest. J Biol Chem, 1997; 272(11): 7093
- 6. Harvat BL, Seth P, Jetten AM. The role of P27 kipl in gamma interferon-mediated growth arrest ofmammary epithelial cells and related defects in mammary carcinoma cells. Oncogene, 1997; 14 (17): 2111
- 7. Liu J, Flanagan WM, Drazba JA, et al. The CDK inhibitor, P27 kipl is required for IL-4 regulation ofastrocyte proliferation. J Immuno, 1997; 159: 812
- 8. Musgrove EA, Swarbrick A, Lee CS, et al. Mechanisms of cyclin-dependent kinase inactiviation byprogestins. Mol cell Biol, 1998; 18 (4): 1812
- 9. Tikoo R, Casaccia-Bonnefil P, Chao PAV, et al. Changes in cyclin-dependent kinase 2 and p27kiplaccomany glial cell differentiation of cestral glia-4 cells. J Biol Chen, 1997; 272(1): 442
- 10. Casaccia-Bonnefil P,Tkoo K,Kiyokawa H,et al. Oligodendrocyte precursor diffcrentiation is perturbedin the absence of the cyclindopendent kinase inhibitor p27kipl. Genes Dev, 1997; 11 (18): 2335
- 11. Furuya Y,Ohta S,Ito H. Apoptosis of androgen-independent mammary and prostate cell lines inducedby topoisomerase inhititors: common pathway of gene regulation. Anticancer Res, 1997; 17 (3c): 2089
- 12. Morosetti R, Kawamata N, Gombart AF, et al. Alterations of the p27kipl gene in non-Hodgkin'slymphomas and adult T-cell Leukamia/lymphoma. Blood, 1995; 86 (5): 1924
- 13. Spirin KS,shopson JF, Takeuchi S, et al. p27/kipl mutation found in breast cancer. Cancer Res, 1996; 56(10): 2400
- 14. Kawamata N,Morosetti R,Miller CW,et al. Molecular analysis of the cyclin-depcndent kinase inhibitorgene p27kipl in human malignancies. Cancer Res, 1995; 55 (1 ): 226
- 15. Lloyd RV,Jin L,Qian X et al. Aberrant expression in endocrine and other tumors. Am J Pathol, 1997;150 (2): 40
- 16. Jin L, Qian X, Kulig E, et al. Transforming growth ractor-beta transforming growth factor-betareceptor,and p27kipl expression in nontwmorous and neoplastic human pituitares. Am J Pathol, 1997;151 (2): 509
- 17. Loda M,Cukor B,Tam SW,et al. Increased proteasome-dep endent degradation of the cyclin-dependentkinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med, 1997; 3 (2): 231
- 18. Singh SP, Lipman J, Goldman H, et al. Loss or altered subcellular localization of p27 in Barrett'sassociated adenocarcinoma. Cancer Res, 1998; 58 (8): 1730
- 19. Craig C,Wersto R,Kimm,et al. A recombinant adenovirus expression p27kipl induces cell cycle arrestand loss of cyclin-Cdk activity in human breast cancer cells. Oncogene, 1997; 14(19): 2283