足月妊娠羊水过少血栓素、前列环素及胎盘组织血栓素受体表达的研究A study of thromboxane and prostacyclin and thromboxane receptor expression in placenta of oligohydramnios.
柳美莲;李宏;邵小光;王志坚;邵淑娟;
摘要(Abstract)：
目的:检测羊水过少孕妇静脉血中血栓素B2(TXB2)、6-酮前列腺素(6-keto-PGF1α)及胎盘组织中血栓素受体(TP)的表达,探讨其与羊水过少发病的关系。方法:ELISA法检测孕妇静脉血中TXB2、6-keto-PGF1α水平,Western blot检测胎盘组织TP含量,免疫组织化学法检测TP的表达及分布。结果:羊水过少孕妇血浆中TXB2、6-keto-PGF1α水平无明显变化,但胎盘组织TP蛋白表达增加,主要于滋养细胞层、绒毛间质表达。结论:胎盘滋养细胞层、绒毛间质TP表达增加,可能参与了羊水过少的发生。
关键词(KeyWords)： 羊水过少;前列腺环素;受体,血栓烷;胎盘
基金项目(Foundation): 课题基金[No:大卫科发(2007)75-25]
作者(Authors): 柳美莲;李宏;邵小光;王志坚;邵淑娟;
DOI: 10.13283/j.cnki.xdfckjz.2010.05.012
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