正常早孕与流产患者蜕膜局部PRL、P、E_2水平及其受体表达水平的比较Comparison of PRL、P、E_2 levels and their receptors expression in normal and abortional decidue
李昆明,归绥琪,蒋立辉,刘承权
摘要(Abstract):
目的 :比较正常早孕组与流产组蜕膜催乳素 (PRL)、孕酮 (P)、雌二醇 (E2 )及其受体水平的差异 ,探讨它们在维持早孕中的作用。方法 :收集正常早孕人工流产 18例与保胎失败流产的 12例蜕膜组织 ,应用放免法测定蜕膜匀浆PRL、P、E2 水平 ,并用免疫组化方法检测了相应激素受体 (PRLR、PR、ER)的表达。结果 :正常早孕组蜕膜匀浆PRL、P水平显著高于流产组 (P <0 .0 5 ) ,正常早孕组PRLR、PR表达亦显著高于流产组 (P <0 .0 5&0 .0 1)。结论 :蜕膜局部正常水平的PRL、P及其受体的正常表达对维持妊娠有重要作用
关键词(KeyWords): 蜕膜;流产;催乳素;受体,催乳素;孕酮;受体,孕酮;雌二醇;受体,雌二醇
基金项目(Foundation):
作者(Author): 李昆明,归绥琪,蒋立辉,刘承权
DOI: 10.13283/j.cnki.xdfckjz.2003.01.014
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