GST-π和DNATopoⅡ在晚期宫颈癌组织中的表达Expressions of GST-πand DNA TopoⅡ in advanced cervical cancer
张广平,陈惠祯,李琳
摘要(Abstract)：
目的：探讨谷胺甘肽Ｓ－转移酶、脱氧核糖核酸拓扑Ⅱ的表达与晚期宫颈癌化疗的关系。方法：应用免疫组化Ｓ－Ｐ法检测２８份晚期宫颈癌组织化疗前后ＧＳＴ－π和ＤＮＡＴｏｐｏⅡ的表达。结果：化疗前２８份宫颈癌组织中ＧＳＴ－π过表达１７份（６０．７１％)，ＤＮＡ ＴｏｐｏⅡ低表达１６份（５７．１４％）；化疗后ＧＳＴ－π过表达２４份（８５．７１％），ＤＮＡ ＴｏｐｏⅡ低表达１８例（６４．２８％）。化疗前后ＧＳＴ－π的表达差异有显著性（Ｐ＜0．05），ＤＮＡ ＴｏｐｏⅡ的表达差异无显著性（Ｐ＞０．０５），二者表达有相关性（Ｐ＝０．０１９）。ＧＳＴ－π过表达和ＤＮＡＴｏｐｏⅡ低表达与患者的化疗反应呈负相关（Ｐ＝０．０１４，Ｐ＝０．０３８）。结论：ＧＳＴ－π过表达与宫颈癌内在性耐药和获得性耐药有关，ＤＮＡ TｏｐｏⅡ低表达只与宫颈癌内在性耐药有关。ＧＳＴ－π和ＤＮＡ TｏｐｏⅡ的表达均能很好地预测晚期宫颈癌患者的化疗耐药与反应。
关键词(KeyWords)： 糖蛋白类;谷胺甘太转移酶类;DNA解旋酶;宫颈肿瘤;药物疗法
基金项目(Foundation):
作者(Author): 张广平,陈惠祯,李琳
DOI: 10.13283/j.cnki.xdfckjz.2000.04.005
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