氟康唑单纯口服及联合硝呋太尔片治疗外阴阴道假丝酵母菌病合并需氧菌性阴道炎的疗效观察Efficacy of oral fluconazole single therapy and oral fluconazole combined with nifuratel vaginal tablets therapy in the treatment of vulvovaginal candidiasis combined with aerobic vaginitis
卢晓博;李星烁;李会阳;王辰;韩姹;武文娟;闫晔;田文艳;王颖梅;薛凤霞;
摘要(Abstract):
目的:比较口服氟康唑胶囊与口服氟康唑胶囊联合阴道放置硝呋太尔片治疗外阴阴道假丝酵母菌病(VVC)合并需氧菌性阴道炎(AV)混合感染的疗效,探讨VVC合并AV的合适治疗方案。方法:收集2014年1月至2016年11月天津医科大学总医院收治的VVC合并AV患者173例。将患者随机分为两组:89例给予口服氟康唑治疗(单药组),84例给予口服氟康唑胶囊联合阴道放置硝呋太尔片治疗(双药组),统计两组的治愈率、有效率及复发率。结果:173例患者中,91.9%为VVC合并轻、中度AV患者。单、双药组中,VVC合并轻、中度AV患者的治愈率、有效率均高于合并重度AV患者。单、双药组间比较,VVC合并轻、中度AV的治愈率(轻度:76.4%vs 73.5%,中度:77.3%vs 90.5%)、有效率(轻度:94.5%vs 93.9%,中度:95.5%vs 100.0%)差异均无统计学意义(P>0.05)。结论:对于VVC合并轻、中度AV的患者,单纯口服氟康唑可取得氟康唑与硝呋太尔联合用药相同的治疗效果。
关键词(KeyWords): 外阴阴道假丝酵母菌病;需氧菌性阴道炎;氟康唑胶囊;硝呋太尔片;治疗
基金项目(Foundation): 国家自然科学基金(No:81471419);; 天津市自然科学基金(No:16JCYBJC26400)
作者(Authors): 卢晓博;李星烁;李会阳;王辰;韩姹;武文娟;闫晔;田文艳;王颖梅;薛凤霞;
DOI: 10.13283/j.cnki.xdfckjz.2018.05.001
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