冻融胚胎移植时间与子宫内膜转化时间对妊娠结局的影响The impacts of frozen-thawed embryo and different endometrial transformation time on pregnancy outcomes
王余江;樊琳;梁嘉颖;黄莉;陈创奇;刘顿;刘风华;张曦倩;
摘要(Abstract):
目的:探讨冷冻胚胎移植周期(FET)中冻融胚胎移植时间与孕酮作用内膜时间对临床结局的影响。方法:回顾分析2013年8月至2016年1月在广东省妇幼保健院生殖中心行FET周期的1609例不孕患者的妊娠结局,按孕酮作用内膜时间(天)-移植第几天胚胎(天)分为3-3组、3-4组、4-3组和4-4组。结果:各组患者的基本特征之间均无统计学差异。孕酮作用内膜时间与移植胚胎时期同步时,4-4组的种植率(37.3%)明显高于3-3组(25.4%)(P<0.05)。孕酮作用内膜4天时,4-3组的种植率与临床妊娠率(23.4%,34.4%)明显低于4-4组(37.3%,53.1%)(P<0.05)。3-3组和3-4组、3-3组和4-3组及3-4组和4-4组的临床妊娠率、种植率和流产率均无统计学差异(P>0.05)。结论:冻融胚胎移植中,同时延迟孕酮作用时间与胚胎移植时间到第四天有更好的临床结局。移植相同天数胚胎时,孕酮作用内膜3天和4天的临床结局无差异。
关键词(KeyWords): 孕酮;子宫内膜;冻融胚胎移植;临床结局
基金项目(Foundation): 广东省医学科研基金(No:B2019019; No:A2020061);; 广州市科技计划项目(No:201704020217)
作者(Authors): 王余江;樊琳;梁嘉颖;黄莉;陈创奇;刘顿;刘风华;张曦倩;
DOI: 10.13283/j.cnki.xdfckjz.2021.01.030
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