刘晓娟;耿女;王辰;闫晔;范爱萍;韩姹;王颖梅;薛凤霞;

• 1:天津医科大学总医院妇产科

摘要(Abstract)：

目的:分析外阴阴道假丝酵母菌病(VVC)疾病严重程度的相关影响因素。方法:将2011年8月~2015年8月就诊于天津医科大学总医院普通妇科门诊的237例重度VVC患者及同期490例轻中度VVC患者作为研究对象进行病例对照研究。采用Logistic回归模型进行单因素及多因素分析。结果:(1)单因素分析显示,年龄≥30岁(OR=0.658,95%CI为0.481~0.899,P=0.009)、已婚(OR=0.560,95%CI为0.394~0.794,P=0.001)、采用自然避孕法避孕(OR=0.588,95%CI为0.359~0.965,P=0.036)、有妊娠史(OR=0.565,95%CI为0.411~0.777,P=0.000)、有阴道分娩史(OR=0.557,95%CI为0.371~0.835,P=0.005)是重度VVC的保护因素。白假丝酵母菌感染(OR=5.678,95%CI为2.180~14.789,P=0.000)是重度VVC的危险因素。对食物、药物或花草过敏(OR=1.713,95%CI为0.982~2.988,P=0.058)是重度VVC的可疑危险因素。(2)多因素分析显示,白假丝酵母菌感染(OR=4.593,95%CI为1.700~12.414,P=0.003)以及对药物、食物或花草过敏(OR=2.172,95%CI为1.059~4.458,P=0.034)是重度VVC的独立危险因素。结论:白假丝酵母菌感染以及对药物、食物或花草过敏是重度VVC的独立危险因素。

关键词(KeyWords)： 外阴阴道假丝酵母菌病;严重程度;危险因素

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(No:81471419)

作者(Author): 刘晓娟;耿女;王辰;闫晔;范爱萍;韩姹;王颖梅;薛凤霞;

Email:

DOI: 10.13283/j.cnki.xdfckjz.2016.05.001

参考文献(References)：

• [1]刘朝晖,廖秦平.外阴阴道假丝酵母菌病(VVC)诊治规范修订稿[J].中国实用妇科与产科杂志,2012(6):401-402
• [2]张岱,刘朝晖,廖秦平,等.外阴阴道假丝酵母菌病病原学及疾病严重程度相关因素的研究[J].实用妇产科杂志,2010(12):906-909
• [3]Liu XP,Fan SR,Peng YT,et al.Species distribution and susceptibility of Candida isolates from patient with vulvovaginal candidiasis in Southern China from 2003 to 2012[J].J Mycol Med,2014,24(2):106-111
• [4]Buchta V,Matula V,Kestranek J,et al.Is diabetes mellitus a risk factor in genital yeast infections?[J].Ceska Gynekol,2013,78(6):537-544
• [5]Dou N,Li W,Zhao E,et al.Risk factors for candida infection of the genital tract in the tropics[J].Afr Health Sci,2014,14(4):835-839
• [6]Ogouyemi-Hounto A,Adisso S,Djamal J,et al.Place of vulvovaginal candidiasis in the lower genital tract infections and associated risk factors among women in Benin[J].J Mycol Med,2014,24(2):100-105
• [7]Nyirjesy P,Alexander AB,Weitz MV.Vaginal Candida parapsilosis:pathogen or bystander?[J].Infect Dis Obstet Gynecol,2005,13(1):37-41
• [8]Williams DW,Jordan RP,Wei XQ,et al.Interactions of Candida albicans with host epithelial surfaces[J].J Oral Microbiol,2013,5
• [9]Kumar CP,Kumar SS,Menon T.Phospholipase and proteinase activities of clinical isolates of Candida from immunocompromised patients[J].Mycopathol,2006,161(4):213-218
• [10]Carvalho LP,Bacellar O,Neves N,et al.Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis[J].J Allergy Clin Immunol,2002,109(1):102-105
• [11]Fan SR,Liao QP,Liu XP,et al.Vaginal allergic response in women with vulvovaginal candidiasis[J].Int J Gynaecol Obstet,2008,101(1):27-30
• [12]Fischer G.Chronic vulvovaginal candidiasis:what we know and what we have yet to learn[J].Australas J Dermatol,2012,53(4):247-254
• [13]Witkin SS.Immunologic factors influencing susceptibility to recurrent candidal vaginitis[J].Clin Obstet Gynecol,1991,34(3):662-668