林继慧;吕映频;祁秀娟;丁钰;刘霞;郭晓静;王静远;

• 1:青岛大学附属医院

摘要(Abstract)：

目的:分析控制性超促排卵患者卵泡液中基质细胞衍生因子-1(SDF-1)和血管内皮生长因子(VEGF)的相关性,初步探讨SDF-1在卵巢过度刺激综合征(OHSS)发生中的作用。方法:选取因输卵管因素或男性因素行IVF/ICSI助孕治疗的72例患者。根据Golen标准分组:中、重度OHSS组26例(A组),无或轻度OHSS者46例(B组),ELISA法检测卵泡液中SDF-1、VEGF水平并进行相关性分析。结果:中、重度OHSS组的卵泡液SDF-1和VEGF水平为(3976.26±3150.92)pg/ml和(171.02±94.56)pg/ml,均显著高于无或轻度OHSS组[(1615.5±1542.68)和(126.23±86.32)pg/ml],差异有统计学意义(P=0.001,P=0.045)。中、重度OHSS组患者卵泡液中SDF-1与VEGF浓度和血清HCG日E2浓度有相关性(r=0.457,P=0.019;r=0.261,P=0.027)。结论:SDF-1可能参与或促进了OHSS的发生发展。

关键词(KeyWords)： 基质细胞衍生因子;血管内皮生长因子;卵巢过度刺激综合征;体外受精-胚胎移植

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 林继慧;吕映频;祁秀娟;丁钰;刘霞;郭晓静;王静远;

DOI: 10.13283/j.cnki.xdfckjz.2016.03.008

参考文献(References)：

• [1]Nastri CO,Ferriani RA,Rocha IA,et al.Ovarian hyperstimiilation syndrome:pathophysiology and prevention[J].J Assist Reprod Gen,2010,27(2/3):121-128
• [2]Nishigaki A,Okada H,Okamoto R.Concentrations of stromal cell-derived factor-1 and vascular endothelial growth factor in relation to the diameter of human follicles[J].Fertil Steril,2011,95(2):742-746
• [3]Nishigaki A,Okada H,Okamoto R.The concentration of human follicular fluid stromal cell-derived factor-1 is correlated with luteinization in follicles[J].Gynecol Endocrinol,2013,29(3):230-234
• [4]Golan A,Ronel R,Herman A,et al.Ovarian hyperstimulation syndrome:an update review[J].Obstet Gynecol Surv,1989,44(6):430-440
• [5]李兴,石庆之.基质细胞衍生因子-1及其受体、血管内皮生长因子与肿瘤血管生成的研究进展[J].新医学,2008,39(4):276-278
• [6]Xueqing S,Guangcun Ch,Mingang H,et al.CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression[J].Cancer Metast Rev,2011,29(4):709-722
• [7]Kryczek I,Frydman N,Gaudin F,et al.The chemokine SDF-1/CXCL12 contributes to T lymphocyte recruitment in human pre-ovulatory follicles and coordinates with lymphocytes to increase granulosa cell survival and embryo quality[J].Am J Reprod Immunol,2005,54(5):270-283
• [8]Skinner MK,Schmidt M,Savenkova MI,et al.Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle developmen[J].Mol Reprod Dev,2008,75(9):1457-1472
• [9]Sayasith K,Sirois J.Expression and regulation of stromal cell-derived factor-1(SDF1)and chemokine CXC motif receptor 4(CXCR4)in equine and bovine preovulatory follicles[J].Mol Cell Endocrinol,2014,391(1-2):10-21
• [10]Bourdiec A,Bedard D,Rao CV,et al.Human chorionic gonadotropin regulates endothelial cell responsiveness to interleukin 1 and amplifies the cytokine-mediated effect on cell proliferation,migration and the release of angiogenic factors[J].Am J Reprod Immunol,2013,70(2):127-138
• [11]Sander VD,Michelle M,Eva G,et al.HCG up-regulates hypoxia inducible factor-1 alpha in luteinized granulosa cells:implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum[J].Mol Hum Reprod,2008,14(8):455-464
• [12]Ceradini DJ,Kulkarni AR,Callaghan MJ,et al.Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1[J].Nat Med,2004,10(8):858-864
• [13]Kryczek I,Lange A,Mottram P,et al.CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers[J].Cancer Res,2005,65(2):465-472
• [14]Kijowski J,Baj-Krzyworzeka M,Majka M,et al.The SDF-1-CXCR4 Axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells[J].Stem Cells,2001,19(5):453-466
• [15]李时望,汤绍涛.SDF-1及其受体CXCR4与乳腺癌的研究现状[J].国外医学(外科学分册),2004,31(3):148-149