韩姹;牛秀敏;张慧英;

• 1:天津医科大学总医院妇产科

摘要(Abstract)：

目的:探讨纤溶酶原激活物抑制剂-1(PAI-1)4G/5G基因多态性与天津及河北地区汉族人群中妊娠期糖尿病(GDM)发病及胰岛素抵抗(IR)的相关性。方法:用PCR方法检测GDM组和正常妊娠对照组(每组75例)PAI-1 4G/5G基因型,并分析相关临床资料。结果:GDM组4G/4G基因型频率及4G等位基因频率均高于正常对照组(P<0.05)。GDM组4G/4G基因型孕妇空腹胰岛素、胰岛素抵抗指数均高于5G/5G组(P<0.05)。结论:PAI-1 4G/5G基因多态性与GDM发病相关,4G/4G基因型可能是GDM的易感基因;PAI-1 4G/4G基因型与GDM患者IR的发生有关。

关键词(KeyWords)： 糖尿病,妊娠;胰岛素抵抗;纤溶酶原激活物抑制剂1;基因多态性

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 韩姹;牛秀敏;张慧英;

DOI: 10.13283/j.cnki.xdfckjz.2008.12.011

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