楼微华;周星辰;邱丽华;

• 1:上海交通大学医学院附属仁济医院妇产科上海市教委重点学科上海市妇科肿瘤重点实验室

摘要(Abstract)：

目的:检测上皮性卵巢癌组织原发灶、转移灶中miR-7及其靶标EGFR蛋白的表达,探讨miR-7及EGFR与卵巢癌转移的关系。方法:采用显色原位杂交(CISH)检测miR-7在卵巢癌组织原发灶、转移灶石蜡切片中的表达;采用免疫组化检测EGFR蛋白表达。结果:上皮性卵巢癌转移灶中miR-7表达显著低于原发灶(P<0.05),而EGFR表达显著高于原发灶(P<0.05);miR-7与EGFR表达具有相关性(r=-0.441,P<0.05)。结论:miR-7可能通过EGFR抑制卵巢癌的转移,miR-7可能成为治疗卵巢癌的新靶标。

关键词(KeyWords)： 上皮性卵巢癌;表皮生长因子受体;微小RNA-7;转移

Abstract:

Keywords:

基金项目(Foundation): 国家自然基金委面上项目(No:81072138);; 上海交通大学医工交叉项目(No:YG2010MS24);; 上海交通大学医学院附属仁济医院重点学科项目

作者(Authors): 楼微华;周星辰;邱丽华;

DOI: 10.13283/j.cnki.xdfckjz.2014.05.004

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