熊苗;朱海润;罗艳群;陆继红;王军;黄红玲;李莉;刘阳;陈宇;朱洁萍;

• 1:上海市第六人民医院东院妇产科
• 2:上海市浦东新区光明中医医院
• 3:上海市浦东新区公利医院

摘要(Abstract)：

目的:观察炔雌醇环丙孕酮片对多囊卵巢综合征(PCOS)患者血清抗苗勒氏管激素(AMH)的影响。方法:选取2015年1月²017年6月在上海市第六人民医院东院妇科门诊就诊的年龄202017年6月在上海市第六人民医院东院妇科门诊就诊的年龄20³0岁的PCOS患者63例。患者签署知情同意书后,予以炔雌醇环丙孕酮片治疗3个月。观察治疗前后内分泌、代谢参数的变化,并与年龄、体重匹配的健康女性比较。结果:63例PCOS患者中,50例完成了本研究。治疗前,PCOS患者的血清AMH水平显著高于对照组[(10.87±4.47)ng/ml vs(8.35±4.25)ng/ml,P<0.05],但正常体重患者和超重/肥胖患者之间,血清AMH水平无显著差异。炔雌醇环丙孕酮片治疗3个月,患者的血清AMH显著下降,差异有统计学意义[(8.22±3.03)ng/ml vs(10.85±3.98)ng/ml,P=0.000]。结论:短期使用炔雌醇环丙孕酮片能显著降低PCOS患者的血清AMH水平。

关键词(KeyWords)： 多囊卵巢综合征;抗苗勒氏管激素;炔雌醇环丙孕酮片

Abstract:

Keywords:

基金项目(Foundation): 上海市浦东新区卫计委联合攻关项目的资助(No:PW2013D-6)

作者(Authors): 熊苗;朱海润;罗艳群;陆继红;王军;黄红玲;李莉;刘阳;陈宇;朱洁萍;

DOI: 10.13283/j.cnki.xdfckjz.2018.03.009

参考文献(References)：

• [1]Saleh BO,Ibraheem WF,Ameen NS.The role of antiMüllerian hormone and inhibin B in the assessment of metformin therapy in women with polycystic ovarian syndrome[J].Saudi Med J,2015,36(5):562-567
• [2]Kriseman M,Mills C,Kovanci E,et al.Anti Müllerian hormone levels are inversely associated with body mass index(BMI)in women with polycystic ovary syndrome[J].J Assist Reprod Genet,2015,32(9):1313-1316
• [3]Piouka A,Farmakiotis D,Katsikis I,et al.Anti-Müllerian hormone levels reflect severity of PCOS but are negatively influenced by obesity:relationship with increased luteinizing hormone levels[J].Am J Physiol Endocrinol Metab,2009,296(2):E238-243
• [4]Wiweko B,Maidarti M,Priangga MD,et al.Anti-Müllerian hormone as a diagnostic and prognostic tool for PCOS patients[J].J Assist Reprod Genet,2014,31:1311-1316
• [5]Panidis D,Georgopoulos NA,Piouka A,et al.The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia[J].Gynecol Endocrinol,2011,27(8):587-592
• [6]Plouvier P,Peigne M,Gronier H,et al.Is the suppressive effect of cyproterone acetate on serum anti-Müllerian-hormone levels in women with polycystic ovary syndrome stronger than under oral contraceptive pill?[J].Gynecol Endocrinol,2016,32(8):612-616
• [7]Birch Petersen K,Hvidman HW,Forman JL,et al.Ovarian reserve assessment in users of oral contraception seeking fertility advice on their reproductive lifespan[J].Hum Reprod,2015,30(10):2364-2375
• [8]Pellatt L,Hanna L,Brincat M,et al.Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries[J].J Clin Endocrinol Metab,2007,92:240-245
• [9]Arbo E,Vetori DV,Jimenez MF,et al.Serum antiMüllerian hormone levels and follicular cohort characteristics after pituitary suppression in the late luteal phase with oral contraceptive pills[J].Hum Reprod,2007,22(12):3192-3196
• [10]Zhang Y,Wang SF,Zheng JD,et al.Effects of testosterone on the expression levels of AMH,VEGF and HIF-1αin mouse granulosa cells[J].Exp Ther Med,2016,12(2):883-888
• [11]朱洁萍,滕银成,陶敏芳.炔雌醇环丙孕酮对非肥胖型多囊卵巢综合征患者内分泌代谢的影响[J].上海交通大学学报(医学版),2010,30(2):168-171