宫颈癌组织中环氧合酶-2和诱生型一氧化氮合酶的表达及其意义Clinical study of expression of COX-2 and iNOS in cervical carcinoma.
欧阳艳琼,吴绪峰,陈惠祯,王玉仁,张志强
摘要(Abstract)：
目的 :研究环氧合酶 2 (COX 2 )和诱生型一氧化氮合酶(iNOS)在宫颈癌发生发展中的作用。方法 :用免疫组化方法检测 80例宫颈癌患者COX 2和iNOS的表达水平 ,并以 3 1例宫颈上皮内瘤样病变(CIN)、3 0例慢性宫颈炎症患者和 3 0例正常宫颈上皮为对照组。结果 :(1 )宫颈癌患者COX 2和iNOS表达阳性率分别为 5 8.75 %和 86.2 5 % ,高于CIN、慢性宫颈炎症患者和正常宫颈上皮组 ;(2 )宫颈癌患者COX 2和iNOS的表达水平与临床分期、组织学分型及细胞分化程度无关 (P >0 .0 5 ) ;(3 )伴淋巴结转移的宫颈癌患者COX 2的表达水平略高于不伴淋巴结转移者 ,但差异无显著性 (P >0 .0 5 ) ,而iNOS的表达水平明显高于不伴淋巴结转移者 (P <0 .0 5 ) ;(4 )肿瘤直径≥ 5cm的宫颈癌患者COX 2的阳性表达率明显高于肿瘤直径 <5cm者 (P <0 .0 5 ) ,而iNOS的阳性表达率高于肿瘤直径 <5cm者 ,但差异无显著性 (P >0 .0 5 ) ;(5 )伴宫旁浸润或脉管浸润的宫颈癌患者COX 2和iNOS表达水平明显高于不伴宫旁浸润或脉管浸润者 (P <0 .0 1 ) ;(6)宫颈癌患者COX 2和iNOS的表达之间无相关性 ,而慢性宫颈炎症患者COX 2和iNOS的表达之间有相关性。结论 :宫颈癌患者COX 2和iNOS的表达水平明显上调 ,其表达与宫颈癌的发生发展有关
关键词(KeyWords)： 环加氧酶;一氧化氮合酶;宫颈上皮内瘤样病变;宫颈肿瘤;免疫组织化学
基金项目(Foundation): 湖北省科技厅资助项目 (2 0 0 2AA30 5B0 7)
作者(Author): 欧阳艳琼,吴绪峰,陈惠祯,王玉仁,张志强
DOI: 10.13283/j.cnki.xdfckjz.2003.05.017
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