促性腺激素平抑因子(GnSAF)生理功能的研究进展
代红梅;谢铁男;
摘要(Abstract)：
早在1970年至1980年,已发现卵泡刺激素(FSH)可刺激卵巢产生一种降低垂体对促性腺激素释放激素(GnRH)反应的物质,被命名为促性腺激素平抑因子(GnSAF)。但是GnSAF的临床特征、生物活性至今仍未达成共识。有学者发现,GnSAF的主要生理作用是抵抗雌激素,从而负反馈调节促黄体激素(LH)的分泌。GnSAF主要由小的生长卵泡产生,在月经周期的前半周期升高,排卵前下降。本文旨在介绍GnSAF的生理功能及其在月经周期中与体内多种激素的协同机制。
关键词(KeyWords)： 促性腺激素平抑因子(GnSAF);卵泡刺激素;促黄体激素;促性腺激素释放激素;卵泡;周期性;垂体;卵巢
基金项目(Foundation): 吉林省发改委基金资助项目(No:201019-2)
作者(Authors): 代红梅;谢铁男;
DOI: 10.13283/j.cnki.xdfckjz.2012.12.015
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