多囊卵巢综合征患者早期自然流产的病因学研究进展
方圆;史红敏;刘襄;甄会欣;韩延华;
摘要(Abstract):
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种常见的内分泌代谢紊乱疾病,育龄期妇女发病率约10%[1]。不孕是育龄期患者就诊的主要原因,药物纠正排卵异常,最终获得成功生育的几率也很有限,且妊娠早期(妊娠前3个月)自然流产率高达30%~50%[2],更加大了治疗难度,严重影响着PCOS妇女的生活质量和身心健康。PCOS患者早期自然流产病因的研究,可有助于改善其妊娠结局。
关键词(KeyWords): 多囊卵巢综合征;早期自然流产;病因学
基金项目(Foundation):
作者(Authors): 方圆;史红敏;刘襄;甄会欣;韩延华;
DOI: 10.13283/j.cnki.xdfckjz.2013.05.003
参考文献(References):
- [1]Simoni M,Tempfer CB,Destenaves B,et al.Functional ge-netic polymorphisms and female reproductive disorders:Part I:polycystic ovary syndrome and ovarian response[J].Hum Reprod Update,2008,14(5):459-484
- [2]Nawaz FH,Rizvi J.Continuation of metformin reduces ear-ly pregnancy loss in obese Pakistani women with polycysticovarian syndrome[J].Gynecol Obstet Invest,2010,69(3):184-189
- [3]Heijnen EM,Eijkemans MJ,Hughes EG,et al.A meta-a-nalysis of outcomes of conventional IVF in women withpolycystic ovary syndrome[J].Hum Reprod Update,2006,12(1):13-21
- [4]蒲燕,黄国宁,王亚平,等.偏振光显微镜分析人卵透明带与胚胎发育潜能的关系[J].生殖与避孕,2008,28(6):348-352
- [5]Lasiene K,Vitkus A,Valanciute A,et al.Morphologocalcriteria of oocyte quality[J].Medicina(Kaunas),2009,45(7):509-515
- [6]成俊萍,何冰,黄莉,等.不同病因对卵母细胞透明带、胚胎发育和妊娠结局的影响[J].生殖与避孕,2011,31(4):270-275
- [7]Wood JR,Dumesic DA,Abbott DH,et al.Molecular ab-normalities in oocytes from women with polycystic ovarysyndrome revealed by microarray analysis[J].J Clin En-docrinol Metab,2007,92(2):705-713
- [8]Boomsma CM,Fauser BC,Macklon NS.Pregnancy compli-cations in women with polycystic ovary syndrome[J].Se-min Reprod Med,2008,26(1):72-84
- [9]Dumesic DA,Padmanabhan V,Abbott DH.Polycystic ova-ry syndrome and oocyte developmental competence[J].Obstet Gynecol Surv,2008,63(1):39-48
- [10]Hsieh M,Zamah AM,Conti M.Epidermal growth factor-like growth factors in the follicular fluid:role in oocytedevelopment and maturation[J].Semin Reprod Med,2009,27(1):52-61
- [11]Artini PG,Monteleone P,Toldin MRP,et al.Growth fac-tors and folliculogenesis in polycystic ovary patients[J].Expert Rev Endocrinol Metab,2007,2(2):215-223
- [12]Salmen JJ,Skufca F,Matt A,et al.Role of glutathione inreproductive tract secretions on mouse preimplantationembryo development[J].Bio Reprod,2005,73(2):308-314
- [13]Qiao J,Feng HL.Extra-and intra-ovarian factors in poly-cystic ovary syndrome:impact on oocyte maturation andembryo developmental competence[J].Hum Reprod Up-date,2011,17(1):17-33
- [14]Mukherjee S,Maitra A.Molecular&genetic factors con-tributing to insulin resistance in polycystic ovary syn-drome[J].Indian J Med Res,2010,131:743-760
- [15]Glueck CJ,Wang P,Goldenberg N,et al.Pregnancy out-come among women with polycystic ovary syndrome trea-ted with metformin[J].Hum Reprod,2002,17(11):2858-2864
- [16]Tian L,Shen H,Lu Q,et al.Insulin resistance increasesthe risk of spontaneous abortion after assisted reproduc-tion technology treatment[J].J Clin Endocrinol Metab,2007,92(4):1430-1433
- [17]Sun L,Lv H,Wei W,et al.Angiotensin-converting en-zyme D/I and plasminogen activator inhibitor-1 4G/5Ggene polymorphisms are associated with increased risk ofspontaneous abortions in polycystic ovarian syndrome[J].J Endocrinol Invest,2010,33(2):77-82
- [18]李小永,郑桂英,张世红.多囊卵巢综合征患者胰岛素、胰岛素样生长因子及其受体的表达[J].生殖与避孕,2004,24(5):274-278
- [19]Glueck CJ,Wang P,Goldenberg N,et al.Pregnancy loss,polycystic ovary syndrome,thrombophilia,hypofibrinolys-is,enoxaparin,metformin[J].Clin Appl Thromb Hem-ost,2004,10(4):323-334
- [20]施晓波,张晶,符书馨.多囊卵巢综合征患者早期流产与子宫内膜雌孕激素受体的关系[J].中南大学学报(医学版),2008,33(6):518-522
- [21]Cocksedge KA,Saravelos SH,Wang Q,et al.Does freeandrogen index predict subsequent pregnancy outcome inwomen with recurrent miscarriage[J].Hum Reprod,2008,23(4):797-802
- [22]Cocksedge KA,Li TC,Saravelos SH,et al.A reappraisalof the role of polycystic ovary syndrome in recurrent mis-carriage[J].Reprod Biomed Online,2008,17(1):151-160
- [23]Quezada S,Avellaira C,Johnson MC,et al.Evaluation ofsteroid receptors,coregulators,and molecules associatedwith uterine receptivity in secretory endometria from un-treated women with polycystic ovary syndrome[J].FertilSteril,2006,85(4):1017-1026
- [24]Alok A,Karande AA.The role of glycodelin as an im-mune-modulating agent at the feto-maternal interface[J].J Reprod Immunol,2009,83(1-2):124-127
- [25]Jakubowicz DJ,Essah PA,Seppala M,et al.Reduced ser-um glycodelin and insulin-like growth factor-binding pro-tein-1 in women with polycystic ovary syndrome duringfirst trimester of pregnancy[J].J Clin Endocrinol Metab,2004,89(2):833-839
- [26]Palacio JR,Iborra A,Ulcova-Gallova Z,et al.The pres-ence of antibodies to oxidative modified proteins in serumfrom polycystic ovary syndrome patients[J].Clin ExpImmunol,2006,144(2):217-222
- [27]栾丽霞,朱晓明,马媛,等.胚胎停育绒毛组织中TGF-β1、MMP-9及TIMP-1的表达及意义[J].现代妇产科进展,2012,21(3):179-181
- [28]刘杰,郑洁,程毓芝.MMP-9/TIMP-1在多囊卵巢综合征流产患者子宫内膜的表达[J].中国妇幼保健,2012,27(2):269-271
- [29]Coffey S,Mason H.The effect of polycystic ovary syn-drome on health-related quality of life[J].Gynecol En-docrinol,2003,17(5):379-386
- [30]曹云霞,王玉蓉.多囊卵巢综合征与心理因素的关系[J].实用妇科与产科杂志,2007,23(9):675-678
- [31]Kemeny ME,Schedlowski M.Understanding the interac-tion between psychosocial stress and immune-related dis-eases:a stepwise progression[J].Brain Behav Immun,2007,21(8):1009-1018
- [32]Nelson DB,McMahon K,Joffe M,et al.The effect of de-pressive symptoms and optimism on the risk of spontane-ous abortion among innercity women[J].J WomensHealth(Larchmt),2003,12(6):569-576
- [33]De Leo V,Musacchio MC,Piomboni P,et al.The admin-istration of metformin during pregnancy reduces polycys-tic ovary syndrome related gestational complications[J].Eur J Obstet Gynecol Reprod Biol,2011,157(1):63-66