降调节与非降调节激素替代内膜准备对冻融胚胎移植结局的影响Comparing the effection of endometrial preparation protocols of hormone replacement treatment with or without pituitary suppression on the outcomes of frozen thawed embryo transfer cycles
江成龙;张昌军;
摘要(Abstract)：
目的:比较3.75mg GnRHa降调节激素替代内膜准备方案与单纯激素替代内膜准备方案对冻融胚胎移植(FET)妊娠率的影响。方法:选取1225例(周期)行冻融胚胎移植患者,根据内膜准备方式分为激素替代周期组(A组)417例和降调节激素替代组808(B组)例。比较两组患者的种植率、妊娠率、流产率和生殖激素水平。结果:激素替代周期组和降调节激素替代组患者的种植率分别为33.6%和38.1%,临床妊娠率分别为52.3%和58.8%;两组的种植率和临床妊娠率比较差异均有统计学意义(P<0.05)。降调节激素替代组的黄体酮注射日、ET前1日和ET后第3日LH低于A组,差异有统计学意义(P<0.05)。两组患者的流产率和异位妊娠率比较,差异无统计学意义(P>0.05)。结论:与传统激素替代内膜准备方案比较,3.75mg GnRHa降调节激素替代内膜准备方式可提高冻融胚胎移植妊娠率而不增加流产率。
关键词(KeyWords)： 冻融胚胎移植;垂体降调节;激素替代;内膜准备
基金项目(Foundation):
作者(Authors): 江成龙;张昌军;
DOI: 10.13283/j.cnki.xdfckjz.2015.06.013
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