孕晚期注射乙肝免疫球蛋白阻断乙肝病毒宫内感染的Meta分析Meta-analysis on the effect of hepatitis B immunoglobulin on blocking intrauterine infection of HBV during the third-trimester
李婷;裘佳敏;苗茂华;苏秀娟;段涛;
摘要(Abstract)：
目的:综合评价孕晚期注射乙肝免疫球蛋白阻断乙肝病毒宫内感染的效果和安全性。方法:应用Revman 4.2.10软件,对计算机检索后筛选出的5项随机对照研究采用固定模型进行分析。结果:孕晚期注射HB IG组宫内感染发生率显著低于对照组[RR=0.40,95%CI(0.30,0.54)]。结论:孕晚期注射乙肝免疫球蛋白可有效地阻断乙肝病毒宫内感染。
关键词(KeyWords)： 乙型肝炎免疫球蛋白;肝炎病毒,乙型;宫内感染;妊娠末期;Meta分析
基金项目(Foundation):
作者(Author): 李婷;裘佳敏;苗茂华;苏秀娟;段涛;
Email:
DOI: 10.13283/j.cnki.xdfckjz.2009.03.021
参考文献(References)：
- [1]Chang MH,Chen TH,Hsu HM,et al.Prevention of hepa-tocellular carcinoma by universal vaccination against hep-atitis B virus:the effect and problems[J].Clin CancerRes,2005,11:7953-7957
- [2]Mast EE,Margolis HS,Fiore AE,et al.A comprehensiveimmunization strategy to eliminate transmission of hepati-tis B virus infection in the United States:recommendationsof the Advisory Committee on Immunization Practices(ACIP)part 1:immunization of infants,children,and ad-olescents[J].MMWR Recomm Rep,2005,54:1-31
- [3]Lee C,Gong Y,Brok J,et al.Effect of hepatitis B immuni-sation in newborn infants of mothers positive for hepatitisB surface antigen:systematic review and meta-analysis[J].BMJ,2006,332:328-336
- [4]朱启镕,吕晴,顾心焕,等.阻断乙型肝炎病毒宫内传播的初步研究[J].中华儿科杂志,1995,33:93-94
- [5]贾继东.孕妇注射乙型肝炎免疫球蛋白预防乙型肝炎病毒母婴传播的有关问题[J].中华内科杂志,2007,46:360-361
- [6]Yuan J,Lin J,Xu A,et al.Antepartum immunoprophylaxisof three doses of hepatitis B immunoglobulin is not effec-tive:a single-centre randomized study[J].J Viral Hepat,2006,13:597-604
- [7]Xu Q,Xiao L,Lu XB,et al.Arandomized controlled clini-cal trial:interruption of intrauterine transmission of hepa-titis B virus infection with HBIG[J].World J Gastroen-terol,2006,12:3434-3437
- [8]Li XM,Shi MF,Yang YB,et al.Effect of hepatitis B im-munoglobulin on interruption of HBV intrauterine infec-tion[J].World J Gastroenterol,2004,10:3215-3217
- [9]Zhu Q,Yu G,Yu H,et al.A randomized control trial oninterruption of HBV transmission in uterus[J].Chin MedJ(Engl),2003,116:685-687
- [10]Zhu Q,Lu Q,Gu X,et al.A preliminary study on inter-ruption of HBV transmission in uterus[J].Chin Med J(Engl),1997,110:145-147
- [11]蔡皓东,王玲,刘敏.乙型肝炎病毒感染妊娠妇女拉夫米定的应用及安全性[J].中华肝脏病杂志,2006,14:151-153