邱添;徐亮;程蔚蔚;陈焱;沈虹;

• 1:上海交通大学医学院附属第六人民医院妇产科
• 2:上海交通大学医学院附属国际和平妇幼保健院妇产科

摘要(Abstract)：

目的:探讨不同类型单绒毛膜双羊膜囊(MCDA)双胎选择性宫内生长受限(sIUGR)胎儿的妊娠结局。方法:选取2013年1月至2017年12月上海交通大学医学院附属国际和平妇幼保健院收治的MCDA双胎并发sIUGR的孕妇43例及其86个胎儿为sIUGR组,根据脐动脉血流多普勒波形变化将sIUGR组孕妇分为Ⅰ型23例,Ⅱ型14例,Ⅲ型6例;选取同期分娩的282例无并发症的MCDA孕妇及其564个胎儿作为对照组。分析两组及3种类型sIUGR之间胎儿的妊娠结局,包括分娩孕周、出生体质量、双胎出生体质量差、Apgar评分、宫内死亡率、胎盘重量、脐带异常插入率以及静脉导管和大脑中动脉血流频谱。结果:sIUGR组胎儿分娩孕周明显早于对照组,大胎及小胎的平均出生体质量均明显低于对照组,两胎儿出生体质量差显著大于对照组,大胎及小胎的Apgar评分均明显低于对照组,胎儿宫内死亡率明显高于对照组,胎盘重量显著小于对照组,脐带异常插入率和静脉导管/大脑中动脉血流异常率显著高于对照组,差异均有统计学意义(P<0.01)。sIUGR组Ⅱ型分娩孕周明显早于Ⅰ型和Ⅲ型(P<0.01,P<0.05),大胎和小胎平均出生体质量均显著低于Ⅰ型和Ⅲ型(P<0.01),两个胎儿出生体质量差明显大于Ⅰ型和Ⅲ型(P<0.05),大胎和小胎的Apgar评分均明显低于Ⅰ型和Ⅲ型(P<0.01),胎儿宫内死亡率(42.86%)显著高于I型(4.35%)及Ⅲ型(0%)(P<0.01)。上述指标在Ⅰ型和Ⅲ型之间无显著差异(P>0.05)。三型sIUGR的胎盘重量比较,无显著差异(P>0.05)。结论:MCDA双胎合并sIUGR胎儿的妊娠结局不良,其相关因素包括脐带异常插入、静脉导管和大脑中动脉血流异常。不同类型sIUGR的胎儿预后不同,其中Ⅱ型预后最差,宫内死亡率较高。

关键词(KeyWords)： 单绒毛膜双羊膜囊双胎;选择性宫内生长受限;妊娠结局

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 邱添;徐亮;程蔚蔚;陈焱;沈虹;

DOI: 10.13283/j.cnki.xdfckjz.2018.08.006

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