118例妊娠合并肺动脉高压患者的围生结局分析Analysis of perinatal outcome of 118 pregnant women with pulmonary arterial hypertension
韩姹;高晓丽;董胜雯;王纯;牛秀敏;
摘要(Abstract)：
目的:探讨妊娠合并肺动脉高压患者的妊娠结局及治疗。方法:回顾性分析了1995年1月至2011年6月我院天津医科大学总医院产科收治的118例妊娠合并肺动脉高压患者的临床资料,根据肺动脉收缩压分为轻度组59例(30～49mmHg),中度组38例(50～79mmHg),重度组21例(≥80mmHg),比较各组肺动脉高压病因、心功能级别、终止妊娠孕周和方式及母儿结局。结果:(1)118例患者病因以先天性心脏病和风湿性心脏病为主,分别占58%和19%,肺动脉高压的程度与患者心功能分级呈显著正相关(P<0.01);(2)分娩方式以剖宫产为主,占74.6%,阴道分娩率9.3%,足月分娩率55.9%,早产发生率28.0%,医源性流产16.1%,孕妇死亡率3.4%。重度组的早产发生率、医源性流产发生率、小于胎龄儿、新生儿窒息率、孕妇及新生儿死亡率均高于轻度组(P<0.05),3组剖宫产率比较无统计学差异(P=0.281);(3)中度组1例患者死于充血性心力衰竭;重度组3例患者死亡,其中2例死于肺栓塞,1例死于心力衰竭。结论:妊娠合并肺动脉高压患者的肺动脉压力越高,围生结局越差。重度患者妊娠可危及母婴健康和生命,不宜妊娠;轻度和强烈要求妊娠的中度患者应加强孕期监护和管理。围生期常规应用抗凝药和新型肺血管扩张剂可改善母婴预后;妊娠终止方式以剖宫产为宜。
关键词(KeyWords)： 心脏缺损,先天性;高血压,肺性;产式;剖宫产术;病人
基金项目(Foundation):
作者(Authors): 韩姹;高晓丽;董胜雯;王纯;牛秀敏;
DOI: 10.13283/j.cnki.xdfckjz.2013.02.019
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