生长抑素及其受体在子宫内膜异位症中的研究进展
方晨;黄凤英;
摘要(Abstract):
生长抑素(SST)是人体内分布广泛的一种环状多肽类激素。研究表明,SST具有抑制肿瘤细胞增殖和促进肿瘤细胞凋亡的作用,且该作用主要由靶细胞表面的生长抑素受体(SSTR)介导。子宫内膜异位症(EM)在形态学上虽呈良性表现,但其临床行为却与恶性肿瘤相似,如种植、侵袭、远处转移等。在EM中开展有关生长抑素及其受体的研究,有利于促进生长抑素及其类似物在EM诊疗中的应用,为其诊疗打开新思路。
关键词(KeyWords): 生长抑素;生长抑素类似物;生长抑素受体;子宫内膜异位症
基金项目(Foundation):
作者(Authors): 方晨;黄凤英;
DOI: 10.13283/j.cnki.xdfckjz.2019.07.020
参考文献(References):
- [1] Bedaiwy MA,Alfaraj S,Yong P,et al.New developments in the medical treatment of endometriosis[J].Fertil Steril,2017,107(3):555-565
- [2] Krulich L,Dhariwal AP,McCann SM.Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro[J].Endocrinol,1968,83(4):783-790
- [3] Brazeau P,Vale W,Burgus R,et al.Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone[J].Science,1973,179(4068):77-79
- [4] Reichlin S.Somatostatin[J].New Engl J Med,1983,309(24):1495-1501
- [5] Patel YC.Somatostatin and its receptor family[J].Front Neuroendocrinol,1999,20(3):157-198
- [6] Siler TM,Yen SC,Vale W,et al.Inhibition by somatostatin on the release of TSH induced in man by thyrotropin-releasing factor[J].J Clin Endocrinol Metabol,1974,38(5):742-745
- [7] Vale W,Rivier C,Brazeau P,et al.Effects of somatostatin on the secretion of thyrotropin and prolactin[J].Endocrinol,1974,95(4):968-977
- [8] Richardson UI,,Schonbrunn A.Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture[J].Endocrinol,1981,108(1):281-290
- [9] Alberti KG,Christensen NJ,Christensen SE,et al.Inhibition of insulin secretion by somatostatin[J].Lancet,1973,2(7841):1299-1301
- [10] Boden G,Ryan IG,Eisenschmid BL,et al.Treatment of inoperable glucagonoma with the long-acting somatostatin analogue SMS 201-995[J].New Engl J Med,1986,314(26):1686-1689
- [11] Wang L,Huang X,Chai Y,et al.Octreotide inhibits the proliferation of gastric cancer cells through P300-HAT activity and the interaction of ZAC and P300[J].Oncology Reports,2017,37(4):2041-2048
- [12] Modarai SR,Opdenaker LM,Viswanathan V,et al.Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells[J].BMC Cancer,2016,16(1):941
- [13] Ragozin E,Hesin A,Bazylevich A,et al.New somatostatin-drug conjugates for effective targeting pancreatic cancer[J].Bioorganic Med Chem,2018,26(13):3825-3836
- [14] Huang CZ,Ye YB,Huang AM,et al.Somatostatin Octapeptide Inhibits Cell Invasion and Metastasis in Hepatocellular CarcinomaThrough PEBP1[J].Cell Physiol Biochem,2018,47(6):2340-2349
- [15] Bharti R,Dey G,Banerjee I,et al.Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy[J].Cancer Letters,2017,388:292-302
- [16] Zarogoulidis K,Eleftheriadou E,Kontakiotis T,et al.Long acting somatostatin analogues in combination to antineoplastic agents in the treatment of small cell lung cancer patients[J].Lung Cancer,2012,76(1):84-88
- [17] Unger N,Ueberberg B,Schulz S,et al.Differential expression of somatostatin receptor subtype 1-5 proteins in numerous human normal tissues[J].Exp Clin Endocrinol Diabetes,2012,120(8):482-489
- [18] Demchyshyn LL,Srikant CB,Sunahara RK,et al.Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20[J].Mol Pharmacol,1993,43(6):894-901
- [19] Patel YC,Srikant CB.Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5)[J].Endocrinol,1994,135(6):2814-2817
- [20] Bruns C,Raulf F,Hoyer D,et al.Binding properties of somatostatin receptor subtypes[J].Metabol Clin Exp,1996,45(8 Suppl 1):17-20
- [21] Reisine T.Somatostatin receptors[J].Am J Physiol,1995,269(6 Pt 1):G813-820
- [22] Fasciani A,Quilici P,Biscaldi E,et al.Overexpression and functional relevance of somatostatin receptor-1,-2,and -5 in endometrium and endometriotic lesions[J].J Clin Endocrinol Metabol,2010,95(12):5315-5319
- [23] Annunziata M,Luque RM,Duran-Prado M,et al.Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility[J].Hum Reprod,2012,27(7):2117-2129
- [24] Fastrez M,Artigasb C,Sirtaine N,et al.Value of the 68Ga-DOTATATE PET-CT in the diagnosis of endometriosis.A pilot study[J].Eur J Obstet Gynecol Reprod Biol,2017,212:69-74
- [25] Fastrez M,Marchisello C,Rassy M,et al.Immunohistochemical analysis of somatostatin receptors in endometriosis tissue samples:a retrospective study[J].Int J Gynecol Pathol,2018 [Epub ahead of print]
- [26] Zhao Y,Peng L,Li X,et al.Expression of somatostatin and its receptor 1-5 in endometriotic and cells[J].Exp Ther Med,2018,16(5):3777-3784
- [27] Hasegawa S,Kobayashi N,Tokuhisa M,et al.Clinical usefulness of somatostatin receptor scintigraphy in japanese patients with gastroenteropancreatic neuroendocrine tumors[J].Digest,2017,96(1):13-20
- [28] Tirosh A,Papadakis GZ,Millo C,et al.Prognostic utility of total,68Ga-DOTATATE-avid tumor volume in patients with neuroendocrine tumors[J].Gastroenterol,2017,154(4):998-1008
- [29] Sevket O,Sevket A,Molla T,et al.Somatostatin analogs regress endometriotic implants in rats by decreasing implant levels of vascular endothelial growth factor and matrix metaloproteinase 9[J].Reprod Science,2013,20(6):639-645