杨菁;冯亭亭;孙伟;冯雪花;冯晓军;贾婷;

• 1:武汉大学人民医院生殖中心
• 2:山东中医药大学第二附属医院生殖医学中心

摘要(Abstract)：

目的:探讨高龄(36⁴5岁)患者采用不同超促排卵方案对体外受精-胚胎移植周期妊娠结局的影响。方法:回顾分析484个周期的高龄患者的资料,根据促排卵方案不同将患者分组:GnRH-a长方案组(148个周期)、拮抗剂方案组(165个周期)、GnRHa超短方案组(171个周期),比较3组患者的基本资料及临床结局。结果:GnRH-a长方案组的h CG日LH水平低于拮抗剂方案组和GnRH-a超短方案组,GnRH-a长方案组的Gn时间最长,获卵数、2PN受精数、2PN卵裂数、优质胚胎数及冷冻数最多(P<0.05);GnRH-a超短方案组的Gn用量最多,2PN受精数、2PN卵裂数最少(P<0.05)。3组的h CG日子宫内膜厚度、新鲜周期胚胎移植数、周期取消率、早期流产率、活产率比较,差异均无统计学意义(P>0.05);胚胎种植率及临床妊娠率:GnRH-a长方案组最高,GnRH-a超短方案组最低,两组比较差异有统计学意义(P<0.05)。结论:对于卵巢储备功能相对较好的高龄患者,GnRH-a长方案具有较好的临床结局;对于卵巢储备较差者,拮抗剂方案Gn用量相对少,临床结局尚可,是一种可选择的比较经济的方案。

关键词(KeyWords)： 高龄;体外受精-胚胎移植;GnRH-a长方案;拮抗剂方案;GnRH-a超短方案

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 杨菁;冯亭亭;孙伟;冯雪花;冯晓军;贾婷;

DOI: 10.13283/j.cnki.xdfckjz.2016.11.007

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