cFLIP在早期自然流产绒毛组织的表达及意义The research of the role that cFLIP played in early spontaneous abortion by examing the expression of cFLIP in villi tissue.
罗淄资;姚穗;
摘要(Abstract)：
目的:检测早期正常妊娠及自然流产绒毛组织中细胞凋亡抑制蛋白cFLIPmRNA及其蛋白产物的表达,分析并探讨cFLIP与自然流产的关系。方法:应用RT-PCR法及免疫组化SP法检测cFLIP mRNA及其蛋白产物在20例自然流产患者(研究组)绒毛组织的表达,以同期正常妊娠要求人工流产20例为对照组。结果:研究组绒毛组织中cFLIP mRNA及蛋白表达明显低于对照组,差异有统计学意义(P<0.01)。结论:细胞凋亡抑制蛋白cFLIP参与维持正常妊娠,绒毛组织中其表达下降可能在自然流产的发生中起重要作用。
关键词(KeyWords)： 流产,自然;cFLIP;细胞凋亡;绒毛
基金项目(Foundation):
作者(Authors): 罗淄资;姚穗;
DOI: 10.13283/j.cnki.xdfckjz.2009.06.012
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